Before we delve further into the topic, it’s important for us to understand what are TMCS and HMDO all about. To begin with TMCS or trimethyl chlorosilane is a popular organosilicon compound that has a molecular formula (CH3)3SiCl. This is a colorless and volatile liquid which is quite stable in nature till the time it doesn’t come in contact of water or moisture. In the field of organic chemistry, it is used quite widely. On the other hand, HMDO or hexamethyl disiloxane is another organosilicon compound which has a molecular formula O[Si(CH3)3]2. This colorless and volatile liquid is basically used as a reagent and a solvent in the process of organic synthesis. It is mainly prepared using trimethylsilyl chloride’s hydrolysis.
Applications of TMCS and HMDO
Trimethylchlorosilane is mainly used for the purpose of manufacturing all types of silicon compounds and it is also regarded as the major raw material for preparing hexamethyldisiloxane and hexamethyldisilazane. It can be even used for preparing alkylation agent, and even group protecting agent in the creation of drugs and medicines of utmost importance. Besides, all this the related reactions of this pharma intermediate with alcohol can be easily exploited for producing anhydrous solutions of HCL in alcohols, which later finds use in the mild synthesis of suitable esters from nitriles and carboxylic acid. Likewise, trimethylsilyl chloride is even utilized to silanizse laboratory glassware, making the suitable surfaces even more lipophilic. These are some of the key things that prove that TMCS is an ideal raw material used for creating various other chemicals and end products.
HMDO or Hexamethyldisiloxane is utilized majorly as a popular internal standard for calibrating chemical shift in spectroscopy. It is much more easily handled because it is lesser volatile in nature. HMDO is also used sometimes for crystallizing highly lipophilic compounds because of its poor solvating power. Besides, all of this, HMDO is used as spray on plasters and liquid bandages for the purpose of safeguarding the skin against damages and irritation. Hexamethyl disiloxane has been used worldwide as a major reporter molecular for measuring and evaluating p02 or tissue oxygen tension. It is highly hydrophobic in nature and is also known to exhibit gas solubility at extreme levels.
It has been clearly said in the above section that both HMDO and TMCS are extremely useful pharma intermediates because they are really good as raw materials. They are used for carrying out a number of applications. Complex procedures like preparation of silicon compounds and spectroscopy are also made simple using raw materials of these kinds. Even though these pharma intermediates are really simple to use as far as their niche applications is concerned, it is important for you to store them in the right way so that they don’t get leaked out.