Silanes serve as radical H-donors or as hydride donors, depending upon the type of the silane. There is an array of such types from simple alkylsilanes (Et3SiH), alkylsiloxanes (PMHS, DEMS), over different phenylsilanes (such as PhSiH3) and halosilanes (such as trichlorosilane) up to tris(trimethylsilyl)silane. Such a variety of types of silanes can be derived due to their structure as outstanding radical reducing agents. Silanes are widely used in organic chemistry and Chemcon excels in the manufacture of three important silanes as pharma-intermediates: Hexamethyl Disilazane (HMDS) , Hexamethyl Disiloxane(HMDSO), and Trimethyl Chlorosilane (TMCS).
Hexamethyl Disilazane (HMDS):
Hexamethyldisilazane is a special organosilicon compound that is a derivative of ammonia. It is different from the traditionally known compound because it has trimethylsilyl groups in place of the two hydrogen atoms. It is a colorless liquid that is a popular reagent and precursor to many bases, making the compound a very popular ingredient in different types of organic synthesis and organometallic chemistry.
• Uses and Applications:
This pharma intermediate has many uses as a chemical intermediate, release agent, lubricant, coupling agent, deactivator for chromatographic support materials, silylating agent in pharmaceuticals, adhesion promoter for photoresists on silicon (electronics), as reagent for temporary protection of reactive sites in manufacture of betalactum antibiotics, etc. Amongst these, the main applications of HMDS are in electron microscopy and in semiconductor electronics industry.
Hexamethyl Disiloxane (HMDSO):
Hexamethyldisiloxane is an organosilicon compound with the formula O[Si(CH3)3]2. This volatile colourless liquid is used as a solvent and as a reagent in organic synthesis. It is prepared by the hydrolysis of trimethylsilyl chloride. The molecule is the protypical disiloxane and resembles a subunit of polydimethylsiloxane.
• Uses and Applications:
This pharma intermediate is used as an internal standard for calibrating chemical shift in1H NMR spectroscopy. It is more easily handled since it is less volatile than the usual standard tetramethylsilane but still displays only a singlet near 0 ppm. It has even poorer solvating power than alkanes. It is therefore sometimes employed to crystallize highly lipophilic compounds.It is also used in liquid bandages (spray on plasters) such as cavilon spray, to protect damaged skin from irritation from other bodily fluids. Moreover, Hexamethyl Disiloxane is commonly utilized as a major source of the trimethylsilyl functional group, including Hexamethyl Disilazane in the process of organic synthesis. Thus, HMDSO plays an important role in the manufacture of HMDS.
Trimethyl Chlorosilane (TMCS):
TMCS Manufacturer a colorless liquid with chemical formula, (CH3)3SiCl and boiling point of 57°C; soluble in ether and benzene. It is mainly used as a water-repelling agent.
• Uses and Applications:
This pharma intermediate is used to catalyze difficult to silylate compounds. This reagent is commonly used to create trimethylsilyl esters from organic acids. Also, addition of this pharma intermediate aids in the derivatization of amides, secondary amines and hindered hydroxy groups. Most volatile of the TMS derivatives often elutes at the solvent front of the GC.
Chemcon, is a leading manufacturer of these pharma intermediates which have an array of uses and applications in the field of silane chemistry as listed above.