USFDA Approved Pharmaceutical Industries: India is emerging out as a hub for manufacturing of quality drugs. It has largest no of USFDA approved plants, which has accelerated the development and growth of pharma sector. The manufacturing facilities of Indian pharmaceutical industries registered in USFDA stood at 523 which is remarkably good for any country outside US. Many Indian pharma industries especially in Gujarat have been successful in setting benchmark for manufacturing quality products, as result many global companies have expressed their intensions for making investments worth rs 1,000 crore in the pharma sector of Gujarat. Various Pharmaceutical Intermediates: There are many Pharmaceutical Intermediate Suppliers across Gujarat. CHEMCON speciality chemicals is one of the leading vadodara based company in Gujarat manufacturing pharmaceutical intermediates like Chloromethyl isopropyl carbonate, Trimethyl chlorosilane, Hexamethyl Disiloxane, Hexamethyl Disilazane. This company is becoming increasingly popular due to wide range of applications of above intermediates in various industrial sectors. Chloromethyl isopropyl carbonate (CMIC) Chloromethyl isopropyl carbonate (CMIC) is transparent colourless liquid having molecular formula C9H9ClO3.It is a pharmaceutical intermediate for manufacturing Tenofovir, which is proven medicine for AIDS and Hepatitis B. Trimethyl chlorosilane (TMCS) Trimethyl chlorosilane (TMCS) is also known as trimethylsilyl chloride is an organosilicon compound having molecular formula (CH3)3SiCl. It is a colourless used for silylation in organic synthesis and for producing pseudo halides. Trimethyl silylation is used to increase volatility of non-volatile compounds and thus enabling its gas chromatography. Hexamethyl Disiloxane(HMDSO) Hexamethyl Disiloxane(HMDSO) is colourless liquid having molecular formula [(CH3)3Si]2O.It is a organo silicon compound prepared by hydrolysis of trimethyl chlorosilane. It is mainly used for trimethyl silyl functional group in organic synthesis. It is also used as internal standard for calibration of 1H NMR Spectroscopy. It can be handled easily as it is less volatile. As it is poor solvating agent it is used to crystallize lipophilic compounds. It is used as a polymer for liquid bandages. When HMDSO is injected directly in tissues can be used to generate maps of tumor. HMDS A Organic Silicon Compound: Hexamethyl Disilazane (HMDS) is a organic silicon compound which is colourless liquid in nature having molecular formula [(CH3)3Si]2 NH. The product is usually handled using air-free techniques since it hydrolysis slowly with water. During pyrolysis it is added to generate silylated product to enhance functional group detectability of compounds. It is a ammonia derivative used mainly for organic synthesis. It can also be used to silylate laboratory glassware for making it hydrophobic i.e it is used as silylating agent, as a primer, adhesion promoter for photoresist for manufacturing of semiconductors in electronic industries. CHEMCON Speciality chemicals is a market leader in manufacturing of highest Purity of Chloromethyl isopropyl carbonate (CMIC) and have proven its consistent ability in manufacturing pharma intermediates listed as above and aligning its product quality with highest standards.
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The market for pharmaceutical intermediates in India is expanding day by day. This is mainly due to the fact that people are now turning towards specialty chemicals for the manufacturing of products like medications. In the last few years, India has seen a huge growth in the number of companies manufacturing pharma intermediates like trimethyl cholorosilane and chloromethyl isopropyl carbonate. In Gujarat alone, the demand for specialty chemicals is huge and companies like Chemcon specialty chemicals are manufacturing these intermediates on a large scale to meet the demand. In India Chloromethyl Isopropyl Carbonate is manufactured on a large scale mainly for its usage in the pharmaceutical industry. This is a transparent and colorless liquid which is used across the world for manufacturing a drug named as tenofovir. This drug is used as an anti-hepatitis B and anti-Aids medication. Besides, being a wonderful intermediate in the pharma industry, CMIC is also used in the process of organic synthesis, which makes it one of the highest selling intermediates in the country. CMIC is miscible with methanol and dimethyl fromamide. Trimethyl Chlorosilane in Gujarat is another popular pharma intermediate which is in huge demand due to its usage in the organic chemistry. This organosilicon compound is miscible in Acetone and insoluble in water. Trimethyl Chlorosilane is quite reactive towards nucleophiles and as a result it replaces the chloride. It gives rise to hexamethyldisiloxane through the process of hydrolysis. Besides, all of this trimethyl chlorosilane is also used for cleaning the laboratory apparatus. One of the major reasons behind the popularity of chloromethyl isopropyl carbonate in India is the fact that it is helpful in manufacturing tenofovir. This is the reason why most of the companies, manufacturing this intermediate stress hard upon its storage and handling. As a handling and storage measure, it has been said about this intermediate that you need to wash your hands carefully after handling it. You got to remove all the contaminated clothing once you are done with handling it. Make sure that you avoid any type of contact with your skin or eyes. It is advised that chloromethyl isopropyl carbonate is stored in a container which is kept away from human contact and in a well closed vessel. Even though CMIC remains stable under normal temperature and pressure, it is advised that proper care needs to be taken by everyone who handles it closely. Chemcon specialty chemicals is known to manufacture CMIC and trimethyl chlorosilane along with other popular pharma intermediates like HMDS. All these pharma intermediates are contributing heavily towards the Indian economy as they help in the manufacturing of other prominent products. The rise in demand for these pharma intermediates is expected to increase significantly in the upcoming future as well. With natural resources getting exhausted day by day, people have now started depending on such alternatives. A lot is spent on the research and development of medications around the world and these intermediates seem to be taking a huge chunk of that investment.
Definition of Completion fluidsCompletion fluids or drilling fluids are specially prepared brine fluids that are formulated especially for assisting in oil drilling activities. The completion fluid should be chemically compatible with the reservoir formation. Completion fluids are prepared in a way that their density, flow, and pH level is maintained as per the drill well which helps in the performance of the well production zone. A good completion fluid is an effectively filtered and solid free liquid that adds value to the production oil well bore. They are used to aid drilling boreholes into the earth. Completion fluids are used in completion operations of oil and natural gas wells such as setting screens production liners, packers, down hole valves or shooting perforations into the producing zone. They usually comprise of chlorides and bromides, clear brine liquids but they can be any fluids with the characteristic high density. The global completion fluids market is expected to significantly increase from the $10.86 billion in 2013 to $18.37 billion by 2020, at 7.8% CAGR. The global market is likely to take a hike in their use in the shale activities in the US, Gulf of Mexico, and Canada. The demand is also particularly high in Europe and Asia Pacific region; particularly in China, India, the United Kingdom, and the Netherlands. Completion Fluids India is gaining demand globally because of their considerable production supply in the last few decades. Uses of Completion Fluids The completion fluids are used in deep, high pressure oil and gas wells that do not plug the formation in workover and completion operations and are much better at performing a filtered drilling than the traditional drilling muds. The bromide salt brine liquids like calcium bromide liquid, Sodium Bromide Liquid, and zinc bromide fluids due to their high densities and brine compositions, both desired properties for completion and drilling fluids are used widely for the drilling and completion activities. Density of Calcium Bromide Calcium Bromide, clear brine liquid is used as single salt brine in densities ranging from 11.7 lbs/gal to 15.1 lbs/gal. It is used as a single-salt or a spike fuel that increases densities of other fluids up to 14.2lbs/gal. Sodium Bromide, a salt is used alone or in a combination with sodium chloride or other bromides to form clear workaround and drilling fluids with densities of 8.4-12.5 lbs/gal. Zinc Bromide, a solids-free fluid has a maximum density of 19.2lbs/gal. The bromide fluids have excellent high density that suits perfectly the requirements for making a good completion fluid. But these bromides can be prepared to form varying compositions of multi-salt brines that form excellent drilling, completion, and packer fluids for the oil drilling activities. Preparing multi-salt brines from these bromides forms excellent completion fluids that are needed in the drill formation liquids.
Why Hexamethyl Disilazane is Popular:Hexamethyl Disilazane (HMDS / HMDZ) CAS No. : 999-97-3, is a special organosilicon compound that has trimethlsilyl groups in place of the two hydrogen atoms. This makes Hexamethyl Disilazane a popular pharmaceutical intermediate amongst the pharma intermediates manufacturers. The various uses and applications of HMDS are as follows: It is used as an excellent adhesive promoter. Main characteristic use of any adhesive promoter is as an additive or a primer. HMDS readily reacts with substrates that form a part of the surfaces on which adhesion needs to be implemented. The component silizanes bind with the oxygen atoms of oxidized substrates in a thin wafer that is used in (semiconductor industries) and the methyl atoms provide a hydrophobic layer that has a good resistance against wetting features on the substrates. This application of HMDS helps to rid the surfaces of absorbed water and reduces the surface energy and this promotes the photoresist adhesion of the substrate. Uses of HMDS in Industries: In the semiconductor industry also, the Active Pharma Intermediates Manufacturers (API) find HMDS as a widely used adhesive product. It is used to supplement the adhesion of photoresist on silicon surfaces. It readily reacts with surface hydroxyl groups to form siloxanes. These newly formed siloxanes make the surfaces more hydrophobic and this lead to increased wettability. This helps the semiconductor industry to manufacture effective chips for computers, tablets, and smartphones. Similarly, (HMDS / HMDZ) CAS No. : 999-97-3 is widely used in the paints and coatings industry, to help with the adhesion to the paint and substrate interface, which makes the paint coatings to last for a longer duration. Another useful application of Hexamethyl Disilazane is its use in replacement of the critical drying technique in the dehydration process of the specimens in Scanning Electron Microscopy (SEM). Moreover, HMDS is an excellent agent for silylation of alcohols, phenols, amines, and acids. Production Summary and Structure: All the above applications of HMDS have given new production opportunities to the pharma intermediates manufacturers in global and especially in Chinese market. Comprehensive studies and reports based on such studies provide an insight to the (HMDS / HMDZ) CAS No. : 999-97-3 Suppliers and Manufacturers about the direction to follow the production process in this industry. The studies provide a summary of the structure, uses and applications, definitions in different contexts, and manufacturing technologies that can be helpful to the manufacturers to establish themselves in the industry. Among the topics that are explored are the global markets for HMDS at large and also an insight about the Chinese market that is reported as the market leader in this industry. The points that are explored in such reports mainly consider the production value of HMDS, its capacity, demand/supply ratio, and the import/export activities. An insight into the participant raw materials are also provided that can be leveraged by the manufactures in efficient production. Thus there are plenty of insightful data available, collated for the vast Hexamethyl Disilazane industry.
Silanes serve as radical H-donors or as hydride donors, depending upon the type of the silane. There is an array of such types from simple alkylsilanes (Et3SiH), alkylsiloxanes (PMHS, DEMS), over different phenylsilanes (such as PhSiH3) and halosilanes (such as trichlorosilane) up to tris(trimethylsilyl)silane. Such a variety of types of silanes can be derived due to their structure as outstanding radical reducing agents. Silanes are widely used in organic chemistry and Chemcon excels in the manufacture of three important silanes as pharma-intermediates: Hexamethyl Disilazane (HMDS) , Hexamethyl Disiloxane(HMDSO), and Trimethyl Chlorosilane (TMCS). Hexamethyl Disilazane (HMDS): Hexamethyldisilazane is a special organosilicon compound that is a derivative of ammonia. It is different from the traditionally known compound because it has trimethylsilyl groups in place of the two hydrogen atoms. It is a colorless liquid that is a popular reagent and precursor to many bases, making the compound a very popular ingredient in different types of organic synthesis and organometallic chemistry. • Uses and Applications: This pharma intermediate has many uses as a chemical intermediate, release agent, lubricant, coupling agent, deactivator for chromatographic support materials, silylating agent in pharmaceuticals, adhesion promoter for photoresists on silicon (electronics), as reagent for temporary protection of reactive sites in manufacture of betalactum antibiotics, etc. Amongst these, the main applications of HMDS are in electron microscopy and in semiconductor electronics industry. Hexamethyl Disiloxane (HMDSO): Hexamethyldisiloxane is an organosilicon compound with the formula O[Si(CH3)3]2. This volatile colourless liquid is used as a solvent and as a reagent in organic synthesis. It is prepared by the hydrolysis of trimethylsilyl chloride. The molecule is the protypical disiloxane and resembles a subunit of polydimethylsiloxane. • Uses and Applications: This pharma intermediate is used as an internal standard for calibrating chemical shift in1H NMR spectroscopy. It is more easily handled since it is less volatile than the usual standard tetramethylsilane but still displays only a singlet near 0 ppm. It has even poorer solvating power than alkanes. It is therefore sometimes employed to crystallize highly lipophilic compounds.It is also used in liquid bandages (spray on plasters) such as cavilon spray, to protect damaged skin from irritation from other bodily fluids. Moreover, Hexamethyl Disiloxane is commonly utilized as a major source of the trimethylsilyl functional group, including Hexamethyl Disilazane in the process of organic synthesis. Thus, HMDSO plays an important role in the manufacture of HMDS. Trimethyl Chlorosilane (TMCS): TMCS Manufacturer a colorless liquid with chemical formula, (CH3)3SiCl and boiling point of 57°C; soluble in ether and benzene. It is mainly used as a water-repelling agent. • Uses and Applications: This pharma intermediate is used to catalyze difficult to silylate compounds. This reagent is commonly used to create trimethylsilyl esters from organic acids. Also, addition of this pharma intermediate aids in the derivatization of amides, secondary amines and hindered hydroxy groups. Most volatile of the TMS derivatives often elutes at the solvent front of the GC. Chemcon, is a leading manufacturer of these pharma intermediates which have an array of uses and applications in the field of silane chemistry as listed above.
The oil and gas drilling industry uses calcium zinc, and sodium bromides to prepare high-density, clear drilling fluids. These brine fluids are used in deep, high-pressure oil and gas wells; they do not plug the formation in workover and completion operations, as conventional drilling muds can do. Such bromide salt brine usage led to higher production rates and longer production lifetimes. Calcium bromide is the most popularly used, with zinc and sodium bromides following closely. Calcium Bromide: A clear brine fluid, Calcium Bromide (CaBr2) solution is used as single salt brine in densities ranging from from 11.7 lbs/gal to 15.1 lbs/gal. It is used as a completion, workover, gravel pack, and packer fluid. It can also be used as a spike fluid to increase density in fluids up to 14.2 lb/gal. Due to its inhibitive properties, CaBr2 can help reduce formation damage induced by clay swelling and dispersion. CaBr2is becoming a popular choice in oil and gas drilling, it is, in fact preferred over many other fluids because it mixes easily with all the major zinc and calcium based brines, adjusts the density of other brine systems, is chemically and thermally stable, and is absolutely non-damaging to formation. Sodium Bromide: Sodium Bromide (NaBr), a salt is used alone or in a combination with sodium chloride or zinc bromide to form clear workaround and drilling fluids with densities of 8.4-12.5 lbs/gal. Non-damaging to the formation, it can be mixed with other solutions of bromide and chlorides. It is especially useful when used in formations that are known to have sensitivity towards calcium. When chloride ion is not desirable and when calcium may not be the preferred choice. It is extensively used in situations where formation of waters contains high levels of sulfate or carbonate that may precipitate with the calcium ion. Zinc Bromide: Zinc Bromide is a clear, solid-free brine fluid with minimum density of 19.2 lbs/gal. It is used in completion fluids and offers features and benefits like it is non-damaging to the formation, it is thermally and chemically stable, and It can be blended with other solutions containing bromides and chlorides. It can be used with other bromides and chlorides to prepare non-damaging liquids with densities ranging from 15.1 lbs/gal to 19.2 lbs/gal. It can never be produced as dry material in sufficient quantity to be used in the completion fluid market it can be prepared only as a liquid brine. These bromide based completion fluids are used in both offshore and onshore drilling operations. Recent expansion in drilling activity like deep, high pressure wells have contributed to the rapid growth in this market, accounting to an expected growth from $10.86 billion in 2013 to $18.37 billion by 2020, with a CAGR of 7.8 percent.
Before we delve further into the topic, it’s important for us to understand what are TMCS and HMDO all about. To begin with TMCS or trimethyl chlorosilane is a popular organosilicon compound that has a molecular formula (CH3)3SiCl. This is a colorless and volatile liquid which is quite stable in nature till the time it doesn’t come in contact of water or moisture. In the field of organic chemistry, it is used quite widely. On the other hand, HMDO or hexamethyl disiloxane is another organosilicon compound which has a molecular formula O[Si(CH3)3]2. This colorless and volatile liquid is basically used as a reagent and a solvent in the process of organic synthesis. It is mainly prepared using trimethylsilyl chloride’s hydrolysis. Applications of TMCS and HMDO Trimethylchlorosilane is mainly used for the purpose of manufacturing all types of silicon compounds and it is also regarded as the major raw material for preparing hexamethyldisiloxane and hexamethyldisilazane. It can be even used for preparing alkylation agent, and even group protecting agent in the creation of drugs and medicines of utmost importance. Besides, all this the related reactions of this pharma intermediate with alcohol can be easily exploited for producing anhydrous solutions of HCL in alcohols, which later finds use in the mild synthesis of suitable esters from nitriles and carboxylic acid. Likewise, trimethylsilyl chloride is even utilized to silanizse laboratory glassware, making the suitable surfaces even more lipophilic. These are some of the key things that prove that TMCS is an ideal raw material used for creating various other chemicals and end products. HMDO or Hexamethyldisiloxane is utilized majorly as a popular internal standard for calibrating chemical shift in spectroscopy. It is much more easily handled because it is lesser volatile in nature. HMDO is also used sometimes for crystallizing highly lipophilic compounds because of its poor solvating power. Besides, all of this, HMDO is used as spray on plasters and liquid bandages for the purpose of safeguarding the skin against damages and irritation. Hexamethyl disiloxane has been used worldwide as a major reporter molecular for measuring and evaluating p02 or tissue oxygen tension. It is highly hydrophobic in nature and is also known to exhibit gas solubility at extreme levels. It has been clearly said in the above section that both HMDO and TMCS are extremely useful pharma intermediates because they are really good as raw materials. They are used for carrying out a number of applications. Complex procedures like preparation of silicon compounds and spectroscopy are also made simple using raw materials of these kinds. Even though these pharma intermediates are really simple to use as far as their niche applications is concerned, it is important for you to store them in the right way so that they don’t get leaked out.
Calcium bromide solution can be the right choice for any oil drilling industry that stresses too much on quality and delivering results. The field of completion fluids India is a vast one but calcium bromide is the right chemical to opt for here. Calcium bromide is a white powder which is odorless and reacts strongly when comes in contact of water. It is nothing but the calcium salt of a strong acid known as hydrobromic acid, which is mainly used for generating other prominent compounds. The chemical formula of calcium bromide is CaBr2 and it is used around the world as a drilling chemical. Calcium Bromide Powder is used in freezing mixtures, neuroses medication, photography, fire retardants and food preservatives. However, it is used widely as a completion fluid and aids in oil drilling. It helps in controlling pressure at the time of creating large holes for drilling whether for water, natural gas or oil. As per the current market scenario where, oil drilling industry is becoming bigger and bigger every day, the use of completion and oil drilling fluids like calcium bromide is also increasing. Why is calcium bromide important for the oil drilling industry? Oilfield chemicals and completion fluids like calcium bromide are used widely in long term projects that involve oil and gas resources. Therefore, enhancements in gas and oil exploration field functions depend heavily upon the Completion Fluid being used. Calcium bromide is highly effective because it improves the drilling fluid efficiency a great deal and the oil recovery too is impeccable with calcium bromide. Another major reason behind the success of calcium bromide in the oil drilling industry is that it is readily available with manufacturers of all scales. Calcium Bromide brine is utilized in various clear brine work over or completion fluids that look out for chemicals with densities between 8.4 to 15.3 lb/gal. It can also be used for the purpose of achieving quick density improvements with a low volume increase. In various solutions, it inhibits migration and hydration of specific swelling clays can therefore be used for the desired packer fluids. Even if you are looking to work on regions which are without an access to liquid brine plants, calcium bromide in its dry form can work for you. Why is calcium bromide better than other industry oil drilling chemicals like potassium formate and sodium bromide? There are various reasons why industries prefer calcium bromide over other prominent oil field chemicals such as Sodium Formate, Potassium Formate and Sodium Bromide. One of the important reasons behind this being that calcium bromide mixes easily with all the major zinc and calcium based brines. The calcium bromide fluids can also prevent the migration and hydration of swelling clays. The presence of moisture in large scale oil production processes can easily result in oil flow lines corrosion and therefore, the use of calcium bromide helps in countering such problems. Some of the other advantages of calcium bromide over other oilfield chemicals include: it is chemically and thermally stable and it is absolutely non-damaging to formation. Storage and HandlingThe storage and handling of calcium bromide however can become a concern if it is not paid proper attention to. It should be handled as an industrial chemical and should be worked with only after the right safety requirements are met. It should be stored in a ventilated and dry area.
These are some of the major applications of Calcium Bromide as an oil drilling chemical. It surely aids the oil drilling industry a great deal in making their processes easier. |
AuthorCHEMCON is a leading manufacturer of Pharmaceutical intermediates and Oilfield Chemicals (Completion Fluids). At Chemcon, an ISO 9001:2008 certified company, we manufacture all our products complying GMP guidelines and completion fluids of unmatched purity, complying with highest standards (API-RP-13J) of quality in Oilfield Industry. Archives
February 2017
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